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  • INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE

    Publication number: 20240158398

    Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

    Type: Application

    Filed: April 20, 2023

    Publication date: May 16, 2024

    Inventors: Natasja Brooijmans, Jason D. Brubaker, Paul E. Fleming, Brian Lewis Hodous, Joseph L. Kim, Brett D. Williams, Douglas Wilson, Kevin J. Wilson, Mark Cronin

  • Cooling system for a marine propulsion engine

    Patent number: 7318396

    Abstract: A cooling system for a marine engine incorporates first and second thermally responsive valves which are responsive to increases in temperature above first and second temperature thresholds, respectively. The two thermally responsive valves are configured in serial fluid communication with each other in a cooling system, with one thermally responsive valve being located upstream from the other.

    Type: Grant

    Filed: June 20, 2005

    Date of Patent: January 15, 2008

    Assignee: Brunswick Corporation

    Inventors: David J. Belter, William D. Lanyi, Richard A. Davis, Steve Wynveen, Christopher J. Taylor

  • Endpoint detection apparatus and method for chemical/mechanical polishing

    Patent number: 5308438

    Abstract: An apparatus and method for determining a selected endpoint in the polishing of layers on a workpiece in a chemical/mechanical polishing apparatus where the workpiece is rotated by a motor against a polishing pad. When a difficult to polish layer, i.e., one requiring a chemical change in a surface skin of the layer which skin is then abraded away by a mechanical process is removed from a more easy to polish surface, i.e., one that relies solely on mechanical abrasion and does not need to have a chemically converted skin thereon. The power required to maintain a set rotational speed in a motor rotating the workpiece significantly drops when the difficult to polish layer is removed. This current drop is used to detect the point at which the polishing must be stopped to avoid over polishing effects, i.e., dishing or thinning or removal of the more easily removed underlying material. Thus, an end point in the process can be established.

    Type: Grant

    Filed: January 30, 1992

    Date of Patent: May 3, 1994

    Assignee: International Business Machines Corporation

    Inventors: William J. Cote, John E. Cronin, William R. Hill, Cheryl A. Hoffman

  • Non-linear multicomponent glass fibers from linear primaries

    Patent number: 5972500

    Abstract: Glass fibers of curly habit may be prepared from a heterogeneous melt of blended particles of at least two distinct glasses. Linear glass primaries controllable in pot and marble processing may be prepared from the heterogeneous melts. Fibers prepared from the randomly heterogeneous primaries exhibit a unique biodissolution mechanism and high biodissolution rates. The process is also amenable to other glass fiberization processes, including the rotary process and the sliver process.

    Type: Grant

    Filed: August 28, 1997

    Date of Patent: October 26, 1999

    Assignee: Johns Manville International, Inc.

    Inventors: Stephen Edward Gross, William Henry Kielmeyer, Michael D. Peterson, Jon F. Bauer

  • Method and apparatus for generating velocity commands for a continuously variable transmission

    Patent number: 6223111

    Abstract: A control apparatus for a continuously variable transmission is disclosed. The control apparatus includes a transmission speed sensor which generates an actual velocity signal in response measuring speed of an output shaft of the continuously variable transmission. The control apparatus further includes a first input device, or speed pedal, which is positionable in one of an infinite number of positions and generates a desired velocity signal corresponding to the position of the speed pedal. The control apparatus yet further includes a controller operable to receive the desired velocity signal, receive the actual velocity signal, calculate a commanded acceleration ac, and generate a commanded velocity Vc based on the desired velocity signal, a jerk value j, and the commanded acceleration ac. A method of controlling a continuously variable transmission is also disclosed.

    Type: Grant

    Filed: April 8, 1999

    Date of Patent: April 24, 2001

    Assignee: Caterpillar Inc.

    Inventors: Michael G. Cronin, Brian D. Kuras, Kevin J. Lueschow, Jerry D. Marr

  • Inhibitors of activin receptor-like kinase

    Patent number: 11634422

    Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

    Type: Grant

    Filed: May 29, 2020

    Date of Patent: April 25, 2023

    Assignee: Blueprint Medicines Corporation

    Inventors: Natasja Brooijmans, Jason D. Brubaker, Paul E. Fleming, Brian Lewis Hodous, Joseph L. Kim, Brett D. Williams, Douglas Wilson, Kevin J. Wilson, Mark Cronin

  • Component mounting system for a marine engine

    Patent number: 7137378

    Abstract: An attachment and support system is provided for supporting a flame arrestor and cover at a preselected position relative to a throttle body which, in turn, is attached to an air intake manifold. A support member is attached, by four bolts, to the air intake manifold. The four bolts, or alternative attachment components, simultaneously attach the throttle body to the air intake manifold and the support member to the throttle body. Both the flame arrestor and cover are attached, by a stud, to the support member.

    Type: Grant

    Filed: May 2, 2005

    Date of Patent: November 21, 2006

    Assignee: Brunswick Corporation

    Inventors: Matthew W. Jaeger, William C. Martin, Jerry M. Stoll, Jr.

  • Variable prism eyeglasses

    Patent number: 8157375

    Abstract: The present invention is directed to an eyeglass device that has manually variable prisms to correct strabismus; that is, double vision. The variable prism eyeglasses consist of an eyeglass frame that holds two primary rings in position and provides baseline reference points for alignment. Prism lenses and corrective lenses fit inside the primary rings and allow the two prism lenses of each primary ring to rotate independently and to hold the corrective lens fixed in place relative to the primary rings. Detent channels on the upper surface and lower surface of the primary rings are the means by which the prisms are adjusted. Each prism lens is moved and positioned via a prism lens pin located in the base of each prism lens. The prism lens pins fit into the detents in the detent channels of the primary ring. The detent selected determines the amount of corrective power the prisms will produce.

    Type: Grant

    Filed: March 21, 2011

    Date of Patent: April 17, 2012

    Inventors: John V. Cronin, William C. Cronin

  • METHODS AND DEVICES FOR ACCESSING A BODY CAVITY USING A SURGICAL ACCESS DEVICE WITH MODULAR SEAL COMPONENTS

    Publication number: 20100312063

    Abstract: Methods and devices are provided for providing access through tissue to a surgical site. In one embodiment, a surgical access device can include a hollow tubular member and a modular seal member. The modular seal member can be configured to radially span a lumen of the tubular member and can be removably and replaceably matable to a portion of the tubular member. The access device can also include a plurality of access ports, each of which can be configured to mate with the modular seal member at a respective desired location.

    Type: Application

    Filed: June 5, 2009

    Publication date: December 9, 2010

    Applicant: ETHICON ENDO-SURGERY, INC.

    Inventors: Christopher J. Hess, Kyle P. Moore, Daniel H. Duke, Daniel J. Mumaw, Katherine J. Schmid, Michael S. Cropper, Jeffrey D. Messerly, William B. Weisenburgh, II, Jerome R. Morgan, Michael D. Cronin, Denzel Z. Herrera-Davis, Gregory W. Johnson, Kevin L. Houser, Frederick E. Shelton, IV

  • System and method for providing different values of jerk in response to speed pedal displacement

    Patent number: 6038504

    Abstract: A system and process for providing different levels of jerk in response to speed pedal displacement in a machine including a speed pedal having a range of displacement, a continuously variable transmission, a mechanism for measuring output speed of the continuously variable transmission, and an electronic controller for generating a jerk command signal that is in a one-to-one correspondence with the displacement of the speed pedal and shaping the jerk command signal into a velocity profile command that is applied to the continuously variable transmission and then comparing the output speed of the continuously variable transmission with the velocity profile command for controlling the continuously variable transmission.

    Type: Grant

    Filed: April 13, 1998

    Date of Patent: March 14, 2000

    Assignee: Caterpillar Inc.

    Inventors: Michael G. Cronin, Brian D. Kuras, Jerry D. Marr

  • SCHOLAR STARTER SYSTEM

    Publication number: 20190066044

    Abstract: This invention relates to a system and method for distributing new products in the selected regions, such as university, college by incentivizing a member, such as students of the university, from the same region. The scholar starter network includes; key student module, new student module, new school module, new company module, ordering application module, tracking module, key student database, school database and product database. The key students are incentivized by the university and/or the product supplier to promote sales of the product on their campus. The university sets the parameters for distribution, including but not limited to, distribution locations, product types, and distribution enticements. Key students utilize a mobile app to view and order available products to at least one of the university approved distribution sites. Products progress through the supply chain is tracked by NFC tags in the product packaging and reported to the key student's mobile app.

    Type: Application

    Filed: August 24, 2018

    Publication date: February 28, 2019

    Inventors: John Cronin, Michael D'Andrea, William M. Peters, SR., William M. Peters, JR.

  • On deck wagering

    Patent number: 12002325

    Abstract: A method of wagering on micro markets that are not related to the current play. For example, wagering on the outcome of the third batter due up in the inning.

    Type: Grant

    Filed: November 9, 2021

    Date of Patent: June 4, 2024

    Assignee: AdrenalineIP

    Inventors: Casey Alexander Huke, John Cronin, Joseph W. Beyers, Michael D'Andrea

  • System and Method for Allowing Students to Trade Product In a Campus

    Publication number: 20200286140

    Abstract: Methods and apparatus consistent with the present disclosure may allow students or other individuals to purchase product from or to trade products with their peers when both a purchaser and a distributor are physically located within a same general location. In such instances, the purchaser and a product distributor may be located within the boundaries of a school or campus that may span only a few city blocks. Both the purchaser and the distributor may both be members of an organization associated with the general location. Methods and apparatus consistent with the present disclosure may allow a purchaser to order products that they need for delivery by another student without either student having to travel to a retail store to pick up an ordered product. Apparatus consistent with the present disclosure may receive information from a product tag as an ordered product is processed for delivery.

    Type: Application

    Filed: March 8, 2019

    Publication date: September 10, 2020

    Inventors: John Cronin, Michael D'Andrea, Charles Root, JR., William M. Peters, JR., William M. Peters, SR.

  • Method of displaying sports news related to a placed wager

    Patent number: 11961361

    Abstract: A method of displaying sports news relevant to at least one wager being considered by the user. For example, news about a particular player.

    Type: Grant

    Filed: July 14, 2021

    Date of Patent: April 16, 2024

    Assignee: AdrenalineIP

    Inventors: Casey Alexander Huke, John Cronin, Joseph W. Beyers, Michael D'Andrea

  • Laternal field emmission devices and methods of fabrication

    Patent number: 5308439

    Abstract: Lateral cathode field emission devices and methods of fabrication are set forth. Conventional integrated circuit fabrication techniques are advantageously used to produce the lateral FEDs. Cathode tips on the order of several hundred angstroms are consistently obtained as well as exact spacing of the cathode to gate and cathode to anode. Various cathode and device configurations are described, including a circular field emission device. A single integrated structure having multiple cathodes and multiple gates is possible to perform various logic operations and/or enhance current output from the device. Multiple field effect devices, with cathodes disposed parallel or perpendicular to the substrate, are integrally coupled through a sharing of one or more metallization layers definitive of the elements of the devices. Significant advantages in current density and circuit layout can be obtained. Methods for fabricating the various devices are also explained.

    Type: Grant

    Filed: February 4, 1993

    Date of Patent: May 3, 1994

    Assignee: International Business Machines Corporation

    Inventors: John E. Cronin, Kent E. Morrett, Michael D. Potter, Timothy D. Sullivan

  • At-bat/per drive wagering

    Patent number: 11928938

    Abstract: A micro market focused on which batters will bat in an inning, for example, a very high price on the ninth man due up in an inning, but a low price for the fourth batter. This approach is a variation of betting on the number of plays in a football drive.

    Type: Grant

    Filed: July 14, 2021

    Date of Patent: March 12, 2024

    Assignee: AdrenalineIP

    Inventors: Casey Alexander Huke, John Cronin, Joseph W. Beyers, Michael D'Andrea

  • Specially shaped contact via and integrated circuit therewith

    Patent number: 6734564

    Abstract: An integrated circuit device including a contact via having a non-cylindrical bottom portion is disclosed. Also a contact via with non-parallel side walls is disclosed. The contact vias are selectively positioned in the integrated circuit device.

    Type: Grant

    Filed: January 4, 1999

    Date of Patent: May 11, 2004

    Assignee: International Business Machines Corporation

    Inventors: John Edward Cronin, Anthony Kendall Stamper

  • Manifold for laparoscopic seal assembly

    Publication number: 20110306842

    Abstract: A laparoscopic seal assembly includes a seal cap having a seal with an access opening. The seal cap also includes a manifold connection for attachment of a functional apparatus. The seal assembly further includes a retractor.

    Type: Application

    Filed: November 6, 2007

    Publication date: December 15, 2011

    Inventors: James W. Voegele, Christopher J. Hess, William B. Weisenburgh, II, Robert P. Gill, Daniel W. Drew, Frank L. Lyman, Michael D. Cronin

  • Iris valve ring

    Patent number: D573711

    Type: Grant

    Filed: March 1, 2007

    Date of Patent: July 22, 2008

    Assignee: Ethicon Endo-Surgery, Inc.

    Inventors: Gregory W. Johnson, Michael D. Cronin, Andrew T. Beckman, William J. White, Chester O. Baxter, Daniel W. Drew

  • Protective device for cell phones

    Patent number: D675604

    Type: Grant

    Filed: January 11, 2012

    Date of Patent: February 5, 2013

    Assignee: Britecase LLC

    Inventors: Jamie Limber, William D. Henz, II, Jay C. Cronin

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